Insulin-Like Growth Factor-1, commonly referred to as IGF1 is a polypeptide hormone that belongs to the growth factor hormone family. This is a naturally produced hormone in all human beings with production primarily occurring in the liver, and to a degree in the peripheral tissues.
IGF1 is a protein hormone comprised of a string of 70 amino acids. IGF1-LR3 (Long R3 Insulin-Like Growth Factor-1) is an 83 amino acid analog of human IGF1. It is comprised of IGF1 sequence with an Arg substitution at the 3rd position, as well as an added 13 amino acid peptide. This composition actually makes IGF1-LR3 2-3 times more potent than standard IGF1 When using this form, this does not change the activity of the IGF1 hormone in any way. The only thing that differs is the overall potency.
IGF1 is a highly anabolic hormone that affects numerous areas of the human body. It also shares an important relationship with Human Growth Hormone (HGH), and on a structural basis is similar to insulin. IGF1 is primarily used to treat IGF1 deficiencies. However, it is also used in patients who do not respond to HGH. With this type of therapy, the individual may very well have plenty of HGH in his system but for one reason or another is not responding to the hormone.
IGF1 largely functions by supporting growth through the enhancement of amino acids, glucose, and fatty acids. As it shares a close relationship with insulin, it can also affect your blood sugar levels. The use of IGF1 can potentially lower your blood sugar significantly resulting in a hypoglycemic state. Due to the enhancement of fatty acids, this further creates the ability to promote body fat, which is definitely a potential downside to use. However, the upside can make it worthwhile if a well-planned diet and lifestyle are in place when supplementing with exogenous IGF1.
IGF1 has been shown to greatly increase the number of cells in the skeletal muscle, which in turn can lead to an enhancement in lean tissue growth.
This occurs by activating the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. Not only can it promote muscle growth, but by this mode of action, it can also promote bone growth, and to a degree growth of internal organs. IGF1 also shares a close relationship to HGH, another powerful and naturally produced hormone by all human beings. HGH, like IGF1, is anabolic and IGF1 is largely responsible for a large portion of the anabolic action provided by HGH. This includes two primary traits that are commonly associated with anabolism in nitrogen retention and protein synthesis. Enhanced nitrogen retention is important due to the fact that all lean tissue is comprised of approximately 16% nitrogen. When nitrogen stores fall, this can send the individual into a catabolic (muscle wasting) state.
IGF1 also plays important role in healing and recovery. This is very apparent when we consider the hormone’s role in the production of connective tissue. IGF1 will also improve collagen function. Collagen is found in all connective tissue in the body. An improvement in collagen function results in stronger bones, as well as strength in the muscles for proper movement. It can even affect the skin and blood vessels in a positive way. IGF1 will also promote cartilage repair and promote enhanced bone density making it an excellent hormone in cases of needed rejuvenation and repair. Finally, this hormone is known as a neuroprotector and neuropromotor, which could potentially lead to improved mental function. This factor could potentially be very beneficial to the elderly when issues of dementia arise. However, further study is still required in order to fully understand the effects, but they do appear to be promising.